Hemophilia
Case

A 24-year-old white man has a diagnosis of hemophilia at the age of about 5 to 6 years. He has recently visited the hematology clinic for the follow-up after hospitalization for an accidental knife cut that caused excessive bleeding. The patient has a history of excessive bleeding from tooth extraction, excessive bruising since childhood and the upper gastrointestinal bleeding in the past three years. He has reported chronic pain of his joints and ankles and denied hemarthroses. The patient has given reports about the episodes of excessive bleeding treatment by use of factor VIII and fresh frozen plasma (Remor, 2013).

The patient has the FVIII deficiency (hemophilia A) which is a common type of hemophilia that affects about 5, 000 males at births. The disease approximately affects about 25, 000 people in the United States. Individuals with hemophilia suffer from deficiencies in clotting factor. The mild hemophilia bleedings problems do mainly occur after surgery, trauma and injury. The condition can accompany some symptoms. Almost 25% of the population with hemophilia has the mild deficiency. Those with moderate hemophilia experience bleeding episodes after minor injuries and may lead to spontaneous episodes of bleeding. The server hemophilia happens after trauma, injury and surgery. It has the spontaneous bleeding into muscles and joints characteristics. Recurrent bleeding of the joints also known as hemarthrosis causes hemophilic arthropathy that causes disability at a very young age (Department of Genetics 2015).

Causes

Hemophilia is a disease happening as a result of gene mutation, and it is a genetic disease. About 70% of hemophilia cases are inheritable from parents. However, the other 30% of patients do not have the family history. In such cases, the main cause of the condition is by a spontaneous gene mutation during the fertilization stage. Hemophilia is also a condition that is linked to sex since the FIX and FVIII geneses are found on the X chromosome. It is the chromosome X that determines the gender of the baby. Thus, the condition’s clinical manifestation has a link to sex. Therefore, females may not express the bleeding symptom like the males (McPhee, & Hammer, 2012).

Pathophysiology
The main source of factor VIII (FVIII) production is thought to be from the reticuloendothelial and the liver system. Transplantation of the liver can correct FVIII deficiency to persons with hemophilia. It is because of the increasing cases of individuals with mild hemophilia having progressive liver diseases. Thus, it is an indication that the liver is the main site for FVIII synthesis (Cayir, Yavuzer, and Sayli, 2014).

The RNA messenger for FVIII is also detectable in spleen and liver among other issues. Studies indicate that the production of FVIII in cells lines that are transferable show that after synthesis the FVIII shifts to the endoplasmic reticulum lumen. It is then within other protection that functions in regulating secretion. It particularly regulates the immunoglobulin binding protein in which it has to dissociate in a process that depends on energy. The FVIII’s signal peptide cleavage, as well as oligosaccharides, also takes place in the endoplasmic reticulum. The calnexin, chaperone proteins, and calreticulin, enhance both FVIII degradation and secretion. Regarding genes, the location of the FVIII (F8C) is at the X chromosome arm at Xq28 region. This gene becomes large comprising of 25 intones and 26 exons. A mature FVIII will have about 2332 amino acids. FVIII deficiency is as a result of gene inversion that causes disrupt to the FVIII gene. The disruptions are insertions, point mutations, and deletions. The low levels of FVIII happen as results of external FVIII gene defects (Huether, &McCance, 2012).

Welcome to GradEd Overseas Consultants Pvt Ltd., your one-stop shop for all your study abroad needs. We are a team of experienced consultants passionate about helping students achieve their study abroad dreams. We understand that studying abroad can be daunting, but we are here to make it as easy as possible for you.
In addition to these advantages, studying in the US can help you develop your English language skills, which can be a valuable asset in your career. It can also allow you to network with other international students and professionals, which can help you to build your career.
“Studying in New Zealand offers a unique and enriching experience for international students. Renowned for its high-quality education system, stunning landscapes, and welcoming culture, New Zealand has become an increasingly popular destination for students seeking to complete their graduation.
In this comprehensive guide, we will delve into various aspects of studying in New Zealand, including the education system, universities, admission requirements, scholarships, cost of living, and student life.
Studying in Austdiverse range of courses, and vibrant multicultural environment. This comprehensive guide will provide you with detailed information about studying in Australia, including the education system, universities, admission requirements, visa process, cost of living, and student life.ralia has become increasingly popular among international students due to its high-quality education system.

Introduction
The oil market is normally oligopoly since the industry normally has a few firms although the large proportion of the output in the industry shared among a few firms. Oil is one of the commodities heavily traded in the entire world. The oil demand, on the other hand, normally prices inelastic as a result of the versatility in its uses. The fluctuations in the oil prices play a significant role in the impacts for the oil exporters/producers as well as the fact that most of the nations around the world are dependent on oil being their chief energy source.

Body

Saudi Arabia is among the most rapidly growing nations in the greater Middle East regions. The development of the country’s oil sector is the main attribute that has been making it possible for the major improvement of the county’s position in the context of the international community. The evident increase energy needs in the world have contributed to the rapid development of the nations that have major oil productions, with Saudi Arabia the main country. The economy of Saudi Arabia is heavily dependent upon their oil industries. The ministry of petroleum, as well as mineral resources, offers the estimation that more than 90% of the expert in the country are normally from the proceeds of the oil export (Fattouh 2013). The export of oils into the world markets contributes more than 40% of the country’s GDP. Additionally the common assertion is that Saudi Arabia is world’s second largest producer of crude oil as well as an exporter.

For decades, the Saudi Arabian economic development has been dependent on their strong success in the oil industry. The country is world’s largest producer as well as exporter of the petroleum products and at the same time is a second largest producer of crude oil after Russia. Their economy is also dependent on the oil as well as the oil related industries encompassing the refinery of petroleum as well as petrochemicals. At the same time, Saudi Arabia is the biggest consumer of energy in the Middle East countries mainly as a result of their growing population as well as the large-scale development projects they are undertaking (Aissaoui 2013). The large government subsidies on fuel as well as the historically high prices of oil are the main causes that have been stimulating domestic consumption.

Considering the country’s high levels of production, it accounts for approximately 13% of world’s oil output and consequently almost 35% of the overall OPEC annual oil productions. The country has become a major determinant of the world oil demand as well as supply implying that the country’s oil production policies cold have a far-reaching effect on international oil prices (Naimi, 2012). From the 1970s, Saudi Arabia has been using their dominance to influence the prices of oil and consequently further their objectives in the sustenance of the long-term oil consumption. Additionally they have been using their dominance to promote their economic stability in the context of the industrialized world.

Reserves
Research indicates that Saudi Arabia possesses approximately 266 billion of oil reserves that have already proven which accounts for 16% of all the proved oil reserves in the world. Even though the country has approximately 100 main oil as well as gas fields, over 8 of their fields are normally located in the country’s northeast portion (Fattouh and van der Linde 2011). The giant Ghawar oil field is the world’s biggest field in the context of production as well as overall remaining reserves.

Production
The country produced an average of 11.8 million bbl/d of the overall oil liquids in the year 2013. The total production of the petroleum products, however, declined by 0.14 million bbl/d from the year 2012 which was their first decline since the year 2009 (Fattouh and van der Linde 2011). Additionally the country declined it oil production in the year 2013 with the objective of accommodating the non-OPEC production development from the country as Canada as well as the US.

Processing
Saudi Aramco is the firm that operates the world’s biggest oil processing facility in addition to a crude oil stabilization plant. It additionally possesses a crude oil processing capacity of over 7 million bbl/d. The efforts by Saudi Arabia to maintain their leading position in the international oil market has been the foundation of their economic policies from the beginning of the 1990s. Although the country has been making attempts aimed at diversifying their economy, the development of a self-propagating mo oil sector has been a very difficult task for the Saudi planners (Naimi, 2012). The government none the less has been able to offer above-average living standards for its citizens as well as the development of a world-class infrastructure basis as well as the social services. However, the sustenance of these living standards, however, is greatly dependent chiefly on the spending of the government which relies on the revenues from its oil industries. In this case, it is not possible for the Saudi Arabian government to neglect their oil industry as it has proven to be their chief economic engine.

The development of the oil industry is additionally a significant attribute in the promotion of the domestic political stability. In the early production days, it was evident that there was going to be the reduction in the Russia as well as from the other OPEC countries. Consequently, the country realized an opportunity to develop their disproportionate share of the net increment in the crude oil demand over the following years. With the objective of realizing their endeavor, the country focused on expanding their oil industry and consequently augments their production capacities. Also, the country embarked on the plans for upgrading their refineries with the objective of meeting the contemporary environmental standards in the west as well as their growing domestic demand.

The oil production in Saudi Arabia negatively correlated with those of other OPEC producing nations and consequently has been highly volatile although the country has not experienced any political shocks. Saudi Arabia sets its oil output in the anticipation that there is going to be the reaction of the fringe as well as maximize their profits relying on the residual demand (Naimi, 2012). The additional evident that is available from the various literature is that Saudi does not vary the output of their oil industries about the demand changes in the international markets. Instead of Saudi acting as the dominant oil producer, the country adopts a tit for tat strategy in punishing their members who produce beyond their quotas while at the same time rewarding those who normally comply.